Jul 24

That morning cup of joe may be just what you need to help jumpstart your workday and sharpen your mind. But if you find yourself repeatedly heading over to the coffee pot for refills, you may be actually putting your brain health at risk. Too much coffee can increase the risk of dementia, warns a new study.

Drinking six or more cups a day was linked with a 53 percent increased risk of dementia and make stroke more likely, too. Brain imaging reveals that drinking a lot of coffee was also associated with brain shrinkage, say scientists.

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When people undergo a great trauma or other unsettling event—they have lost a job or a loved one dies, for example—their understanding of themselves or of their place in the world often disintegrates, and they temporarily “fall apart,” experiencing a type of depression referred to as existential depression. Their ordeal highlights for them the transient nature of life and the lack of control that we have over so many events, and it raises questions about the meaning of our lives and our behaviors. For other people, the experience of existential depression seemingly arises spontaneously; it stems from their own perception of life, their thoughts about the world and their place in it, as well as the meaning of their life. While not universal, the experience of existential depression can challenge an individual’s very survival and represents both a great challenge and at the same time an opportunity—an opportunity to seize control over one’s life and turn the experience into a positive life lesson—an experience leading to personality growth.

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Antibody Contract Manufacturing Market is estimated to be worth USD 17 billion in 2030, predicts Roots Analysis

 

The benefits of engaging a CMO or CDMO for antibody development and production extend beyond fulfilling the needs of small companies; access to new technologies and operational flexibility are attractive attributes to larger players as well

 

Roots Analysis is pleased to announce the publication of its recent study, titled, “Antibody Contract Manufacturing Market, 2020-2030” report to its list of offerings.

The report features an extensive study of the current market landscape and future opportunities associated with the contract manufacturing of antibodies. The study also features a detailed analysis of key drivers and trends related to this evolving domain. In addition to other elements, the study includes:

·        A detailed review of the overall landscape of companies, offering contract services for the manufacturing of antibodies.

·        A competitiveness analysis of key players engaged in this domain, featuring an assessment based on their supplier strength and service strength.

·        A benchmark analysis, highlighting the key focus areas of small, mid-sized and large companies, comparing their existing capabilities within and beyond their respective (geography-based) peer groups.

·        An analysis of the various partnerships pertaining to contract manufacturing of antibodies, which have been established since 2013.

·        An analysis of the various expansion initiatives undertaken by service providers, in order to augment their respective antibody manufacturing capabilities, over the period 2017-2019 (till October).

·        An estimate of the overall, installed capacity for manufacturing antibodies based on data reported by industry stakeholders in the public domain.

·        Informed estimates of the annual commercial and clinical demand for antibodies, based on various relevant parameters, such as target patient population, dosing frequency and dose strength.

·        Elaborate profiles of the key industry players that offer contract manufacturing services at all scales of operation and have more than two manufacturing facilities.

·        A case study comparing the key characteristics of large molecule and small molecule drugs, along with details on the various steps and challenges involved in their respective manufacturing processes.

·        A discussion on affiliated trends, key drivers and challenges, under a SWOT framework, which are likely to impact the industry’s evolution.

Request for Latest Market Insights:

https://www.rootsanalysis.com/reports/view_document/antibody-cmo-market/295.html

A detailed market forecast, featuring analysis of the current and projected future opportunity across key market segments (listed below)

Type of Antibodies

·        Monoclonal Antibodies

·        Bispecific Antibodies

·        ADCs

·        Others

Company Size

·        Small

·        Mid-sized

·        Large / Very Large

Scale of Operation

·        Preclinical / Clinical

·        Commercial

Type of expression system used

·        Mammalian

·        Microbial

Key geographical regions

·        North America

·        Europe

·        Asia and RoW

Transcripts of interviews held with the following senior level representatives of stakeholder companies:

·        Dietmar Katinger (Chief Executive Officer, Polymun Scientific)

·        David C Cunningham (Director, Corporate Development, Goodwin Biotechnology)

·        Claire Otjes (Marketing Manager, Batavia Biosciences)

Market Key Players:

·        AGC Biologics

·        Aldevron

·        AMRI

·        Boehringer Ingelheim BioXcellence

·        Emergent BioSolutions

·        Eurofins CDMO

·        FUJIFILM Diosynth Biotechnologies

·        KBI Biopharma

·        Lonza

·        Nitto Avecia Pharma Services

·        Novasep

·        Pierre Fabre

·        Samsung BioLogics

·        Synthon

·        Thermo Fisher Scientific

For more information, please click on the following link:

https://www.rootsanalysis.com/reports/295/request-customization.html

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Jun 24

Legend has it that Marie Antoinette’s hair turned gray overnight just before her beheading in 1791.

Though the legend is inaccurate—hair that has already grown out of the follicle does not change color—a new study(link is external and opens in a new window) from researchers at Columbia University Vagelos College of Physicians and Surgeons is the first to offer quantitative evidence linking psychological stress to graying hair in people.

And while it may seem intuitive that stress can accelerate graying, the researchers were surprised to discover that hair color can be restored when stress is eliminated, a finding that contrasts with a recent study in mice that suggested that stressed-induced gray hairs are permanent.

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In a study of healthy volunteers, National Institutes of Health researchers have mapped out the brain activity that flows when we learn a new skill, such as playing a new song on the piano, and discovered why taking short breaks from practice is a key to learning. The researchers found that during rest the volunteers’ brains rapidly and repeatedly replayed faster versions of the activity seen while they practiced typing a code. The more a volunteer replayed the activity the better they performed during subsequent practice sessions, suggesting rest strengthened memories.

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Psilocybin, the active compound in magic mushrooms, may be at least as effective as selective serotonin reuptake inhibitors, the leading type of antidepressant medication, according to research published in the New England Journal of Medicine. The phase 2, double-blind, randomized, controlled trial compared psilocybin to the antidepressant medication escitalopram.

“Our previous research in treatment-resistant depression and as well as human brain scanning strongly suggested the therapeutic potential of psilocybin. Pitting psilocybin in a head to head versus a conventional antidepressant felt like a brave and interesting test to do,” said study author Robin Carhart-Harris, the head of the Centre for Psychedelic Research at Imperial College London and founder of MyDelica.

The researchers recruited 59 men and women between the ages of 18 and 80 years who suffered from moderate-to-severe depression for their 6-week trial. Thirty patients were randomly assigned to the psilocybin group, while the remaining 29 patients were assigned to the escitalopram group.

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Ultra-processed foods have known negative implications for health; however, their effect on skeletal development has never been explored. Here, we show that young rats fed ultra-processed food rich in fat and sugar suffer from growth retardation due to lesions in their tibial growth plates. The bone mineral density decreases significantly, and the structural parameters of the bone deteriorate, presenting a sieve-like appearance in the cortices and poor trabecular parameters in long bones and vertebrae. This results in inferior mechanical performance of the entire bone with a high fracture risk. RNA sequence analysis of the growth plates demonstrated an imbalance in extracellular matrix formation and degradation and impairment of proliferation, differentiation and mineralization processes. Our findings highlight, for the first time, the severe impact of consuming ultra-processed foods on the growing skeleton. This pathology extends far beyond that explained by the known metabolic effects, highlighting bone as a new target for studies of modern diets.

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Mind-altering drugs such as psilocybin and MDMA could transform the treatment paradigm for mental health disorders, says neuroscientist David Nutt. But trial design considerations, regulatory hurdles and economics still pose problems for psychedelic-assisted therapies.

Fear of psychiatric hospitalization is one of the primary reasons that older men — an age and gender group at high risk for suicide — don’t talk about suicide with their physicians.

Researchers discovered this finding as part of a pre-launch, stakeholder assessment of a multimedia program designed to encourage men to open up to their primary care providers about suicidal thoughts. Called MAPS, for Men and Providers Preventing Suicide, the program will eventually be integrated into doctors’ office waiting areas.

The MAPS assessment was led by Anthony Jerant, chair of family and community medicine at UC Davis Health, and is published in the journal Patient Education and Counseling.

“Our overall goal is to initiate comfortable conversations with men about mental health and its treatment in outpatient primary care settings,” Jerant said. “Fear of hospitalization wasn’t really on our radar, proving that stakeholder interviews are crucial to shaping the development of suicide-prevention interventions like ours.”

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This new study, published in the journal Nature Communications, reports a method that converts data from an ordinary blood test into a single statistic to determine biological age, as well as understand how it can fluctuate over time in the same person.

The research team from Singapore-based biotech company Gero drew on longitudinal human blood count data from the National Health and Nutrition Examination Survey and UK Biobank. This resulted in a single variable to describe biological age, called the dynamic organism state indicator (DOSI).

Basically, the DOSI is derived from biomarkers in blood and it indicates the resilience of individuals over time. One of the major factors of resilience is the ability to make new cells to repair damage, both regular wear and tear and to overcome diseases and injuries.

The study found that healthy people were very resilient to stresses, while people who had chronic diseases and an elevated risk of mortality were less resilient.

The recovery time also grew longer with age – two weeks for a healthy 40-year-old to six weeks for an 80-year-old. This finding from blood test parameters was compared to and confirmed by physical activity levels recorded by wearable devices.

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Signs of Parkinson’s disease could be detected in the nose years before people develop more obvious symptoms of the condition.

The finding could lead to the development of a nasal swab test for the disorder, similar to ones used for coronavirus testing, and may shed light on its causes, says Werner Poewe at the Medical University of Innsbruck in Austria.

Parkinson’s disease is a condition involving tremors and difficulties in moving that usually starts in later life. It is caused by the death of brain …

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Rep. Cathy McMorris Rodgers’ biggest fear as a parent isn’t gun violence, or drunk driving, or anything related to the pandemic.

It’s social media.

And specifically, the new sense of “brokenness” she hears about in children in her district, and nationwide. Teen depression and suicide rates have been rising for over a decade, and she sees social apps as a major reason.

At a hearing this March on Capitol Hill, the Republican congresswoman from Washington confronted Facebook CEO Mark Zuckerberg, Twitter CEO Jack Dorsey and Google CEO Sundar Pichai with a list of statistics: From 2011 to 2018, rates of teen depression increased by more than 60%, and from 2009 to 2015, emergency room admissions for self-harm among 10- to 14-year-old girls tripled.

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Yoga and breathing exercises have a positive effect on children with attention deficit hyperactivity disorder (ADHD). After special classes, children improve their attention, decrease hyperactivity, they do not get tired longer, they can engage in complex activities longer.

This is the conclusion reached by psychologists at Ural Federal University who studied the effect of exercise on functions associated with voluntary regulation and control in 16 children with ADHD aged six to seven years.

The results of the study are published in the journal Biological Psychiatry.

“For children with ADHD, as a rule, the part of the brain that is responsible for the regulation of brain activity – the reticular formation – is deficient,” said Sergey Kiselev, head of the Laboratory of Brain and Neurocognitive Development at UrFU, head of the study.

“This leads to the fact that they often experience states of inadequate hyperactivity, increased distraction and exhaustion, and their functions of regulation and control suffer a second time. We used a special breathing exercise based on the development of diaphragmatic rhythmic deep breathing – belly breathing. Such breathing helps to better supply the brain with oxygen and helps the reticular formation to better cope with its role. When the reticular formation receives enough oxygen, it begins to better regulate the child’s state of activity”.

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May 16

Eating a diet rich in fruit and vegetables is associated with less stress, according to new research from Edith Cowan University (ECU).

The study examined the link between fruit and vegetable intake and stress levels of more than 8,600 Australians aged between 25 and 91 participating in the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study from Baker Heart and Diabetes Institute.

The findings revealed people who ate at least 470 grams of fruit and vegetables daily had 10 per cent lower stress levels than those who consumed less than 230 grams. The World Health Organization (WHO) recommends eating at least 400 grams of fruit and vegetables per day.

Lead researcher, PhD candidate Simone Radavelli-Bagatini from ECU’s Institute for Nutrition Research, said the study strengthens the link between diets rich in fruit and vegetables and mental wellbeing.

“We found that people who have higher fruit and veggie intakes are less stressed than those with lower intakes, which suggests diet plays a key role in mental wellbeing,” said Ms Radavelli-Bagatini.

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May 15

Intermittent fasting has been recently proposed as an eating pattern strategy to elicit, through the metabolic switch from the use of glucose as a fuel source to the use of fatty acids and ketone bodies, the improvement of insulin resistance, obesity, dyslipidemia, high blood pressure, cognitive functions, resistance to stress, suppression of inflammation, and increased life expectancy.

The first time I dealt with a chiropractor was in 1999 at a mall kiosk, which seemed like an odd place to encounter a medical professional. I was a teenager working a few storefronts down selling butterfly clips, and I made the mistake of looking at one of the kiosk’s spinal models. The chiropractor on duty promptly came over to let me know how he could fix all my health ailments. Back issues! Period pain! Even weight loss! Whatever was ailing me, this chiropractor was on it.

The problem with his sales pitch? I was in perfect health. Nevertheless, he persisted.

Despite his enthusiasm for fixing me, I was skeptical. Who the hell peddles (real) medicine out of a kiosk? Brain surgeons and oncologists aren’t at the mall trying to drum up new business from vulnerable passersby. What could a chiropractor do for me?

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People who reach a very old age may have their genes to thank. Genetic variants that help to prevent DNA mutations and repair any that do occur have been found in supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105, respectively.

“DNA repair mechanisms are extremely efficient in these people,” says Claudio Franceschi at the University of Bologna in Italy. “It is one of the most important basic mechanisms for extending lifespan.”

People often feel nervous when they visit a doctor with some fearing their symptoms may not be believed. But what if you are the doctor, and your colleagues dismiss your disabilities and mental health difficulties? Miranda Schreiber explores this challenging relationship.

health
Created on Jun 17, 2020
By @gurlic